Limited global diversity of the Plasmodium vivax merozoite surface protein 4 gene
نویسندگان
چکیده
منابع مشابه
analysis of plasmodium vivax merozoite surface protein-1 gene sequences
the emergence of plasmodium vivax in dashte moghan in northwestern iran has become a major concern for iranian's health officials. knowledge of genetic make up of the p. vivax populations in this area would give us an insight into the origin of the prevalent infections and the possible routes they are introduced. this paper reports the analysis of a variable region between the two interspecies ...
متن کاملdiversity of merozoite surface protein-3β gene of plasmodium vivax isolates from iran
background: plasmodium vivax malaria accounts for approximately 88% of malaria cases in iran. there is limited information on genetic diversity of p. vivax in the country and a need to develop and apply an effective vaccine against the disease is necessary. among many potential candidates, msp -3β gene is promising target. this study was designed and carried out to determine the variation of...
متن کاملAntigenicity and Immunogenicity of Plasmodium vivax Merozoite Surface Protein-3
A recent clinical trial in African children demonstrated the potential utility of merozoite surface protein (MSP)-3 as a vaccine against Plasmodium falciparum malaria. The present study evaluated the use of Plasmodium vivax MSP-3 (PvMSP-3) as a target antigen in vaccine formulations against malaria caused by P. vivax. Recombinant proteins representing MSP-3α and MSP-3β of P. vivax were expresse...
متن کاملGenetic diversity of Plasmodium Vivax revealed by the merozoite surface protein-1 icb5-6 fragment
BACKGROUND Plasmodium vivax remains a potential cause of morbidity and mortality for people living in its endemic areas. Understanding the genetic diversity of P. vivax from different regions is valuable for studying population dynamics and tracing the origins of parasites. The PvMSP-1 gene is highly polymorphic and has been used as a marker in many P. vivax population studies. The aim of this ...
متن کاملPlasmodium vivax merozoite surface protein-3 alpha: a high-resolution marker for genetic diversity studies.
BACKGROUND & OBJECTIVES Malaria, an ancient human infectious disease caused by five species of Plasmodium, among them Plasmodium vivax is the most widespread human malaria species and causes huge morbidity to its host. Identification of genetic marker to resolve higher genetic diversity for an ancient origin organism is a crucial task. We have analyzed genetic diversity of P. vivax field isolat...
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ژورنال
عنوان ژورنال: Infection, Genetics and Evolution
سال: 2009
ISSN: 1567-1348
DOI: 10.1016/j.meegid.2009.04.017